Risk Factors Genetics may account for about 30% of the predisposition for developing clinical depression. One of the key genes that may be involved is the gene methylenetetrahydrofolate reductase (MTHFR) gene, which is involved in the conversion of folate in the more active form of methyl folate or 5-MTHF. This form of folate is essential for several biological processes, including DNA synthesis and neurotransmitter production (brain messengers such as serotonin).
There are also other genes involved in producing or breaking down the neurotransmitters in the brain, that should be considered, such as COMT, MAO and others. Here, at Naturopath Solutions, we recommend clients with mood issues to have a gene test to see if they have an issue with these genes.
