SIBO Can Lead To:
- Malabsorption of carbohydrates and proteins – Impaired breakdown and absorption of monosaccharides and amino acids.
- Fermentation of sugars by bacteria – Produces hydrogen, methane, and hydrogen sulphide gases that cause bloating, pain, and discomfort.
- Damage to the intestinal lining – These gases and bacterial toxins weaken the gut wall and contribute to inflammation.
- Vitamin malabsorption – Especially vitamin B12 and folate (B9), leading to fatigue and poor immune function.
- Mineral malabsorption – Particularly magnesium, iron, and calcium, which are vital for energy, muscle, and bone health.
- Leaky Gut (Intestinal Hyperpermeability) – Damage to the intestinal barrier allows large particles, toxins, and microbes to pass into the bloodstream, triggering immune responses and systemic inflammation.
Frequently Asked Question: What Is “Leaky Gut”?
Q: Does a “leaky gut” mean there are actual holes in my intestines?
A: That’s a common misunderstanding. The term “leaky gut” is a simplified way to describe a more accurate condition called intestinal hyperpermeability. This doesn’t mean your gut has holes — rather, it means the protective barrier in your small intestine becomes less effective at controlling what passes through into your bloodstream.
The small intestinal lining covers an estimated 250 square metres (2,700 square feet) of surface area. It’s made up of specialised cells connected by tight junctions, which form a selective barrier. When functioning properly, these junctions allow essential nutrients like amino acids, glucose, vitamins, and minerals to pass through, while keeping out toxins and pathogens.
When the gut barrier becomes compromised, partially digested food molecules, toxins, and microbes can leak into surrounding tissues. This triggers the immune system — and since over 70% of immune cells reside in the gut wall, the body’s inflammatory response can affect both digestion and overall health.
What Causes Increased Intestinal Permeability?
The rise in intestinal hyperpermeability — often called “leaky gut” — is closely linked to modern lifestyle factors and dietary habits. Common causes include:
- A Western diet low in fibre and high in processed foods, sugar, and unhealthy fats
- Excessive alcohol consumption
- Overuse of medications such as NSAIDs, antibiotics air jordan 23 howard university pe, and acid-blockers that disrupt gut flora
- Chronic stress and poor sleep
- Food sensitivities — particularly to gluten and other inflammatory proteins
Over time, these factors can weaken the gut lining, alter the microbiome, and increase inflammation, setting the stage for chronic health issues.
Health Conditions Linked to Leaky Gut and SIBO
Scientific studies suggest that increased intestinal permeability may contribute to or exacerbate a range of digestive, autoimmune, and systemic conditions, including:
- Digestive disorders: Celiac disease, Crohn’s disease, Irritable Bowel Syndrome (IBS)
- Autoimmune diseases: Lupus, Hashimoto’s thyroiditis, Type 1 diabetes, Multiple sclerosis
- Inflammatory and metabolic conditions: Arthritis, obesity, chronic fatigue syndrome, fibromyalgia
- Allergic and dermatological issues: Acne, eczema OnlinenevadaShops° , Liberty London x adidas mesa Collection Releases January 10 , adidas mesa glitch world skin cancer center greenwood, and food sensitivities
- Mental health impacts: Mood changes, anxiety, and depression linked to gut-brain axis imbalance
Addressing the underlying causes of intestinal permeability — such as bacterial overgrowth, nutrient deficiencies, and dietary triggers — can play a vital role in restoring gut health and overall wellbeing.