Genetics can account for approximately 30% of the predisposition to clinical depression. One of the key genes implicated is the methylenetetrahydrofolate reductase (MTHFR) gene, which plays a critical role in converting folate into its active form, methylfolate (5-MTHF). This active form of folate is essential for multiple biological processes, including:
- DNA synthesis and repair
- Production of neurotransmitters such as serotonin, , and GABA
- Supporting methylation pathways crucial for brain and metabolic health
Other genes may also affect neurotransmitter production or breakdown in the brain, including COMT, MAO, and several others. Variations in these genes can influence mood regulation, stress response, and overall mental wellbeing.
At Naturopath Solutions , we recommend that clients experiencing mood disorders undergo comprehensive genetic testing to identify potential the best nike air max 95s of all time gene-related vulnerabilities. This enables a personalised, evidence-based approach to supporting mental health, including tailored nutrition, lifestyle, and supplement interventions.